Delayed gastric emptying in Parkinson's disease.
Identifieur interne : 000607 ( Main/Exploration ); précédent : 000606; suivant : 000608Delayed gastric emptying in Parkinson's disease.
Auteurs : Sarah Marrinan [Royaume-Uni] ; Anton V. Emmanuel ; David J. BurnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Gastroparesis, Parkinson Disease.
- physiology : Gastric Emptying.
- physiopathology : Enteric Nervous System, Gastroparesis, Parkinson Disease.
- Humans.
Abstract
Gastrointestinal symptoms are evident in all stages of Parkinson's disease (PD). Most of the gastrointestinal abnormalities associated with PD are attributable to impaired motility. At the level of the stomach, this results in delayed gastric emptying. The etiology of delayed gastric emptying in PD is probably multifactorial but is at least partly related to Lewy pathology in the enteric nervous system and discrete brainstem nuclei. Delayed gastric emptying occurs in both early and advanced PD but is underdetected in routine clinical practice. Recognition of delayed gastric emptying is important because it can cause an array of upper gastrointestinal symptoms, but additionally it has important implications for the absorption and action of levodopa. Delayed gastric emptying contributes significantly to response fluctuations seen in people on long-term l-dopa therapy. Neurohormonal aspects of the brain-gut axis are pertinent to discussions regarding the pathophysiology of delayed gastric emptying in PD and are also hypothesized to contribute to the pathogenesis of PD itself. Ghrelin is a gastric-derived hormone with potential as a therapeutic agent for delayed gastric emptying and also as a novel neuroprotective agent in PD. Recent findings relating to ghrelin in the context of PD and gastric emptying are considered. This article highlights the pathological abnormalities that may account for delayed gastric emptying in PD. It also considers the wider relevance of abnormal gastric pathology to our current understanding of the etiology of PD.
DOI: 10.1002/mds.25708
PubMed: 24151126
Affiliations:
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Le document en format XML
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Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24151126</idno><idno type="pmid">24151126</idno><idno type="doi">10.1002/mds.25708</idno><idno type="wicri:Area/PubMed/Corpus">000698</idno><idno type="wicri:Area/PubMed/Curation">000698</idno><idno type="wicri:Area/PubMed/Checkpoint">000622</idno><idno type="wicri:Area/Ncbi/Merge">003D99</idno><idno type="wicri:Area/Ncbi/Curation">003D99</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D99</idno><idno type="wicri:Area/Main/Merge">000607</idno><idno type="wicri:Area/Main/Curation">000607</idno><idno type="wicri:Area/Main/Exploration">000607</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Delayed gastric emptying in Parkinson's disease.</title><author><name sortKey="Marrinan, Sarah" sort="Marrinan, Sarah" uniqKey="Marrinan S" first="Sarah" last="Marrinan">Sarah Marrinan</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Emmanuel, Anton V" sort="Emmanuel, Anton V" uniqKey="Emmanuel A" first="Anton V" last="Emmanuel">Anton V. Emmanuel</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enteric Nervous System (physiopathology)</term><term>Gastric Emptying (physiology)</term><term>Gastroparesis (complications)</term><term>Gastroparesis (physiopathology)</term><term>Humans</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Gastroparesis</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gastric Emptying</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Enteric Nervous System</term><term>Gastroparesis</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal symptoms are evident in all stages of Parkinson's disease (PD). Most of the gastrointestinal abnormalities associated with PD are attributable to impaired motility. At the level of the stomach, this results in delayed gastric emptying. The etiology of delayed gastric emptying in PD is probably multifactorial but is at least partly related to Lewy pathology in the enteric nervous system and discrete brainstem nuclei. Delayed gastric emptying occurs in both early and advanced PD but is underdetected in routine clinical practice. Recognition of delayed gastric emptying is important because it can cause an array of upper gastrointestinal symptoms, but additionally it has important implications for the absorption and action of levodopa. Delayed gastric emptying contributes significantly to response fluctuations seen in people on long-term l-dopa therapy. Neurohormonal aspects of the brain-gut axis are pertinent to discussions regarding the pathophysiology of delayed gastric emptying in PD and are also hypothesized to contribute to the pathogenesis of PD itself. Ghrelin is a gastric-derived hormone with potential as a therapeutic agent for delayed gastric emptying and also as a novel neuroprotective agent in PD. Recent findings relating to ghrelin in the context of PD and gastric emptying are considered. This article highlights the pathological abnormalities that may account for delayed gastric emptying in PD. It also considers the wider relevance of abnormal gastric pathology to our current understanding of the etiology of PD.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J" last="Burn">David J. Burn</name><name sortKey="Emmanuel, Anton V" sort="Emmanuel, Anton V" uniqKey="Emmanuel A" first="Anton V" last="Emmanuel">Anton V. Emmanuel</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Marrinan, Sarah" sort="Marrinan, Sarah" uniqKey="Marrinan S" first="Sarah" last="Marrinan">Sarah Marrinan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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